Probing and Disrupting Oncogenic Gene Control via Targeted Protein Degradation
- Date: Tuesday, October 13th, 2020
- Time: 7 PM CET
This webinar will outline the use of targeted protein degradation (TPD) to understand transcriptional processes at a high kinetic resolution. TPD is a new therapeutic modality based on small molecules, called degraders, that destabilize proteins by inducing their proximity to E3 ubiquitin ligases. The ubiquinated proteins are then degraded by the proteasome.
In this webinar, Georg Winter of CeMM, the Research Center for Molecular Medicine of the Austrian Academy of Sciences, will discuss his team’s efforts to chart the function of the human Mediator complex by combining acute protein ablation with nascent RNA sequencing approaches.
Speaker: Georg Winter, PhD
Principal Investigator, CeMM, the Research Center for Molecular Medicine of the Austrian Academy of Sciences